منابع مشابه
Plasma F2-isoprostanes and coronary artery calcification: the CARDIA Study.
BACKGROUND Oxidation of lipids in lipoproteins and cells may initiate and enhance the early development of cardiovascular disease. METHOD AND RESULTS We assayed F(2)-isoprostanes, oxidation products of arachidonic acid, by gas chromatography-mass spectrometry in a biracial cohort of 2850 young healthy adult men and women. Coronary artery calcification (CAC), a component of coronary artery ath...
متن کاملHDL is the major lipoprotein carrier of plasma F2-isoprostanes.
Enhanced oxidative stress is implicated in the development of atherosclerosis in humans and animal models. F(2)-isoprostanes are formed in vivo via free radical peroxidation of arachidonic acid, and their quantification has allowed assessment of oxidative stress in vivo. F(2)-isoprostanes associate with lipids, although their distribution in human plasma lipoproteins is unknown. Our aim was to ...
متن کاملUrinary F2-Isoprostanes and Metabolic Markers of Fat Oxidation
Metabolomic studies of increased fat oxidation showed increase in circulating acylcarnitines C2, C8, C10, and C12 and decrease in C3, C4, and C5. We hypothesize that urinary F2-isoprostanes reflect intensity of fatty acid oxidation and are associated with circulating C2, C8, C10, and C12 directly and with C3, C4, and C5 inversely. Four urinary F2-isoprostane isomers and serum acylcarnitines are...
متن کاملIncreased formation of distinct F2 isoprostanes in hypercholesterolemia.
BACKGROUND F2 isoprostanes are stable, free radical-catalyzed products of arachidonic acid that reflect lipid peroxidation in vivo. METHODS AND RESULTS Specific assays were developed by use of mass spectrometry for the F2 isoprostanes iPF2alpha-III and iPF2alpha-VI and arachidonic acid (AA). Urinary excretion of the 2 F2 isoprostanes was significantly increased in hypercholesterolemic patient...
متن کاملAnalytical and biological variation of F2-isoprostanes during the menstrual cycle.
F2-isoprostanes have been advocated as a specific and reliable marker of oxidative damage (1 ) despite a lack of data on their biological and analytical variation. Concurrent with a longitudinal study of oxidative stress during the menstrual cycle [the BioCycle Study (2 )], we have characterized the components of biological and analytical variation of free plasma F2isoprostanes in the context o...
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ژورنال
عنوان ژورنال: Biological Research For Nursing
سال: 2013
ISSN: 1099-8004,1552-4175
DOI: 10.1177/1099800413498507